Search results for "runs of homozygosity islands"

showing 2 items of 2 documents

Runs of homozygosity reveal genome-wide autozygosity in Italian sheep breeds

2018

The availability of dense single nucleotide polymorphism (SNP) assays allows for the determination of autozygous segments based on runs of consecutive homozygous genotypes (ROH). The aim of the present study was to investigate the occurrence and distribution of ROH in 21 Italian sheep breeds using medium-density SNP genotypes in order to characterize autozygosity and identify genomic regions that frequently appeared in ROH within individuals, namely ROH islands. After filtering, the final number of animals and SNPs retained for analyses were 502 and 46 277 respectively. A total of 12 302 ROH were identified. The mean number of ROH per breed ranged from 10.58 (Comisana) to 44.54 (Valle del B…

0301 basic medicineCandidate geneRuns of homozygosity islandCandidate geneSingle-nucleotide polymorphismRuns of HomozygosityBiologyBarbarescaPolymorphism Single Nucleotidesheep breeds03 medical and health sciencessingle nucleotide polymorphismGenotypeGeneticsAnimalsSNPSheep breedGeneticsSheepgenomic inbreedingHomozygotecandidate genes; genomic inbreeding; runs of homozygosity islands; sheep breeds; single nucleotide polymorphism; Animal Science and Zoology; GeneticsGeneral MedicineCandidate genes; Genomic inbreeding; Runs of homozygosity islands; Sheep breeds; Single nucleotide polymorphism; Animal Science and Zoology; Geneticsbiology.organism_classificationBreedruns of homozygosity islandsGenetics Population030104 developmental biologyItalyAnimal Science and Zoologycandidate genesInbreedingAnimal Genetics
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Genome-wide identification of runs of homozygosity islands and associated genes in local dairy cattle breeds

2018

Runs of homozygosity (ROH) are widely used as predictors of whole-genome inbreeding levels in cattle. They identify regions that have an unfavorable effect on a phenotype when homozygous, but also identify the genes associated with traits of economic interest present in these regions. Here, the distribution of ROH islands and enriched genes within these regions in four dairy cattle breeds were investigated. Cinisara (71), Modicana (72), Reggiana (168) and Italian Holstein (96) individuals were genotyped using the 50K v2 Illumina BeadChip. The genomic regions most commonly associated with ROHs were identified by selecting the top 1% of the single nucleotide polymorphisms (SNPs) most commonly…

Male0301 basic medicineCandidate generuns of homozygosity islandGenotypeRuns of homozygosity islands genomic regions candidate genes local dairy cattle bovine beadchip 50KLocus (genetics)Single-nucleotide polymorphismBiologyRuns of HomozygosityPolymorphism Single NucleotideGenomeSF1-1100bovine beadchip 50K; candidate genes; genomic regions; local dairy cattle; runs of homozygosity islands; Animal Science and ZoologySettore AGR/17 - Zootecnica Generale E Miglioramento Genetico03 medical and health sciencesAnimalsInbreedinggenomic regionsGeneDairy cattleGeneticslocal dairy cattleGenomeReproductionHomozygote0402 animal and dairy sciencecandidate gene04 agricultural and veterinary sciences040201 dairy & animal sciencegenomic regionAnimal cultureruns of homozygosity islandsDairyingPhenotype030104 developmental biologybovine beadchip 50KCattleFemaleAnimal Science and Zoologycandidate genesInbreeding
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